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Furthermore, single-cell RNA sequencing-based comparisons of OPCs obtained from young and old mice have revealed mitochondrial dysfunction and a greater activity of the inflammasome and pathways associated with nutrient signaling in aged OPCs (Neumann et al., 2019)

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Not the compound's lipolytic potential

While this synthesis summarises PET-specific evidence, several frequently reported biological pathways (e.g., oxidative stress and inflammation) are not unique to PET and may be driven primarily by particle size, surface properties, dose metrics, and exposure duration rather than polymer identity alone

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A comprehensive review of mitochondrial complex I during mammalian oocyte maturation